Dose-Related Biochemical Markers of Renal Injury After Sevoflurane Versus Desflurane Anesthesia in Volunteers

Abstract

Human (and rat) kidneys are injured by a reactive compound (Compound A) produced by degradation of the clinical inhaled anesthetic, sevoflurane. Injury increases with increasing duration of exposure to a given concentration of Compound A. The response to Compound A has several implications, as discussed in the article.