Combination of Ca²⁺‐activated K⁺ channel blockers inhibits acetylcholine‐evoked nitric oxide release in rat superior mesenteric artery

Abstract

Acetylcholine increases endothelial cell [Ca2+]i by release of stored calcium and calcium influx resulting in activation of apamin and charybdotoxin-sensitive K channels, hyperpolarization and release of NO in the rat superior mesenteric artery.