1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T40b,Since the introduction of reliable, quantitative serologic methods,¹cases of congenital toxoplasmosis have been diagnosed with increasing frequency. However, knowledge of the epidemiology and the pathogenesis of the disease is still deficient. It is known that the fetus is infected in utero because symptoms are manifest at birth and because mothers of children with congenital toxoplasmosis have in all cases shown strongly positive serologic reactions. Nevertheless, the majority of mothers have appeared healthy, without any history of definite illness during pregnancy; on postnatal examination, no characteristic clinical signs of disease have yet been demonstrated. Consequently, we must assume the existence of a mild form of acquired toxoplasmic infection, or perhaps even a form not apparent clinically. Besides such subclinical forms, there have been thus far only few known cases of acquired toxoplasmosis in which significant clinical signs have been present and in which the diagnosis has been verified through1e:T42b,HUMAN toxoplasmosis has been confined largely to congenital infection of infants. Acquired toxoplasmosis with clinical illness in the adult remains a rarity. On the basis of toxoplasmin skin reactivity and demonstrable circulating antibodies there is increasing evidence of widespread infection in man without clinical manifestations. As a result of the development of a new serologic method of diagnosis,¹long series of infants and children with congenital toxoplasmosis have been reported. Sabin and Feldman²reported 23 patients with congenital disease in 1948. Eichenwald³established the diagnosis for 100 patients from 1948 to 1952, and Feldman³found 75 patients from 1949 to 1952. Careful interrogation has uniformly failed to elicit any history of illness attributable to toxoplasmosis, either present or past, in the mothers of infants so affected. However, the mothers of infants with toxoplasmosis always show high Toxoplasma antibody titers, indicative of recent infection. Therefore, it is logical to assume that1f:T21f8,

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