Depressurization of an Expanded Liquid Organic Solution (DELOS): A New Procedure for Obtaining Submicron- or Micron-Sized Crystalline Particles

Abstract

The depressurization of an expanded liquid organic solution (DELOS) crystallization technique is a new eco-efficient, one-step process for the straightforward production of submicron- or micron-sized crystalline particles. This novel method is based upon the large, fast, and very homogeneous temperature decreases experienced by an organic solution, previously expanded with a gaslike compressed fluid (e.g., CO2), when it is depressurized. Through a DELOS process, it is possible to achieve the size reduction of different kinds of organic compounds that are difficult to comminute by conventional techniques.