Regulation of Cholesterol And Bile Acid Homeostasis by the Cholesterol 7α-Hydroxylase/Steroid Response Element-Binding Protein 2/Microrna-33A Axis in Mice

Abstract

This study suggests that a CYP7A1/SREBP2/miR-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis. Antagonism of miR-33a may be a potential strategy to increase bile acid synthesis to maintain lipid homeostasis and prevent nonalcoholic fatty liver disease, diabetes, and obesity.