<i>In Vivo</i>Monitoring of VEGF-Induced Retinal Damage in the Kimba Mouse Model of Retinal Neovascularization

Abstract

In vivo monitoring of retinal vascular and neural retinal changes in the Kimba mice using the Spectralis HRA+OCT imaging device allowed us to assess and track VEGF-induced damages in great detail and in real-time. Real-time monitoring of these changes can be used to study the interplay between VEGF overexpression and other molecular factors and to monitor dynamic retinal changes following therapeutic intervention.