Proinflammatory cytokines and receptor activator of nuclear factor κB-ligand/osteoprotegerin associated with bone deterioration in patients with Crohnʼs disease

Abstract

Bone disease that accompanies CD at diagnosis suggests that bone metabolism is affected by the underlying inflammatory process per se, as probably confirmed by our finding of the central proinflammatory cytokine TNF-alpha being strongly associated with the osteoclastogenic mediator RANKL, and inversely with bone density.