PLP fixation for combined routine histology and immunocytochemistry of liver biopsies.

Abstract

Technical methods donors screened, similar to the proportions of IgA deficient blood donors reported in other British studies.24 None of the 239 sera agglutinated un- coated latex, but 228 agglutinated IgA coated latex directly in the absence of added anti-IgA (including seven of the 18 confirmed IgA deficient sera). With ethical committee approval, follow up serum samples were obtained from the 18 IgA deficient blood donors six months after the initial samples had been taken: 14 of these still showed IgA deficiency (IgA < 0-5 g/l) by laser nephelometry while four had returned to normal serum IgA values. One IgA deficient donor had mild but clinically important recurrent infections (sinusitis, otitis media), two had mild allergies, and two had possible autoimmune disorders. No other important clinical abnormalities were elicited at interview.