Functional evaluation of missense variations in the human <i>MAD1L1</i> and <i>MAD2L1</i> genes and their impact on susceptibility to lung cancer

Abstract

These results suggest that genetic variants in MAD1L1 and MAD2L1 confer susceptibility to lung cancer, which might result from reduced spindle checkpoint function due to attenuated function of MAD1L1 and/or MAD2L1.