Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

Guangchao Sui, Christina Soohoo, El Bachir Affar et al. · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

Alan Eastman · PubMed · 1990 · 406 citations

Life Sciences, Cell Biology, Oncology +17

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

Roger L. Kaspar, Igor B. Rosenwald, Lee Gehrke et al. · Proceedings of the National Academy of Sciences · 1996 · 398 citations

Life Sciences, Cell Biology, Molecular Biology +17

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

Igor B. Rosenwald, Roger L. Kaspar, Dennis L. Rousseau et al. · Journal of Biological Chemistry · 1995 · 269 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Cisplatin as first-line therapy for metastatic breast cancer.

George W. Sledge, Patrick J. Loehrer, Bruce J. Roth et al. · Journal of Clinical Oncology · 1988 · 224 citations

Medicine, Oncology, Pharmacology +17