ATP AND LIPID CONTENTS IN THE LIVER OF MICE AFTER INHALATION OF CHLORINATED HYDROCARBONS

Abstract

The decrease in the hapatic ATP level and the increment of the fatty liver as reflected by the increase in the amounts of the total lipid and triglyceride in the mice exposed to three kinds of chlorinated hydrocarbons are in the following order, carbon tetrachloride, tetrachloroethylene and trichloroethylene. The total lipid and triglyceride contents increase proportionately to the fall in the ATP level with lapse of time in the mice before and after the exposure to three kinds of chlorinated hydrocarbons.From above results, it is inferred that there exists some close relationship between the decreased hepatic ATP levels and the development of fatty liver in the case of chlorinated hydrocarbon poisonings.