The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis

Abstract

The activation and translocation of pStat3 to the nucleus are frequent events in ovarian carcinoma that are associated with a poor prognosis. Further studies are needed to elucidate the mechanism of activation of Stat3, its effects on downstream targets, and its role in the neoplastic transformation of epithelial ovarian cells.