Halogenated, alkylated and new types of imidazolidine, pyrrolidine, imidazotriazine and thienoimidazole derivatives with biological and antitumor activities

Abstract

New types of halogenated, alkylated and (bis)cyanothio-formamides were prepared and reacted with iso(thio)cyanates, aldehydes and dibenzylideneacetone to produce (bis)imidazolidine-imino(di)thiones and (oxazolidine and bispyrrolidine)iminothiones, respectively. Imidazolidineimi-nothiones were reacted with H2S/TEA to give thiohydantoin which reacted with p-chlorobenzaldehyde to achieve the corresponding thienoimidazole derivative. Most of the synthesized products exhibited antibacterial, antifungal and antitumor activities.