Systems Biology in Reproductive Medicine · 2013 · 61 citations · 23 references
PharmacyBiochemistryToxicologyMechanisms Of ToxicityReproductive ToxicologySemen EvaluationMale Reproductive ToxicologyOxidative StressOxidative Stress MechanismsTesticular FunctionTesticular PhysiologyTesticular ToxicologyGlutathione Peroxidase ActivityOxidative Damage To SpermatozoaOxidative Stress Effects On Sperm MotilityOxidative Stress In TestesSperm Count AssessmentSperm Morphometric ParametersSperm ParametersTesticular Oxidative Damage
In order to investigate the effects of molybdenum (Mo) on sperm parameters and testicular oxidative stress, the ICR strain of adult mice were exposed to different doses of molybdenum for a sub-acute toxicity test. Compared to the control, our results showed that the sperm parameters, including the epididymis index, sperm motility, sperm count, and morphology, increased by a moderate dose of Mo (25 mg/L), but were negatively affected at high doses (≥ 100 mg/L). In addition, the changes of sperm parameters were accompanied with changes of the superoxide dismutase (SOD) activities, the glutathione peroxidase (GPx) activities, and the malondialdehyde (MDA) levels in testes. In conclusion, Mo affects the sperm quality through regulating the testicular oxidative stress in a complex manner.
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World Academy of Science, Engineering and Technology 62 2010
Mohammad Moghiman, Mohammad Javadi, امیر رضا مقیمان et al. · 2010 · 3.8K citations
Engineering, Industrial Engineering, Production Engineering +3