Concepedia

Anabolic Effects of Peniel 2000, a Peptide That Regulates TGF-β1 Signaling on Intervertebral Disc Degeneration

Young‐Joon Kwon, Je–Wook Lee, Eun-Joung Moon, Yeon Gu Chung, Ok‐Soon Kim, Hae Jin Kim

Spine · 2012 · 27 citations · 28 references

DOI

Abstract

A novel peptide, P2K, regulating TGF-β1 signaling had an anabolic effect on bovine IVD cells and rabbit degenerated discs. The results suggest that P2K has considerable potential as a treatment of degenerative disc disease.

References

28

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Gareth J. Inman, Francisco José Nicolás, James F. Callahan et al. · Molecular Pharmacology · 2002 · 1.6K citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

Yu Yamaguchi, David Mann, Erkki Ruoslahti · Nature · 1990 · 1.5K citations

, , +10

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

Marie‐José Goumans · The EMBO Journal · 2002 · 1.1K citations · Full text

, , +13

Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor <i>β</i>

A. Hildebrand, Lars Melholt Rasmussen, Dick Heinegård et al. · Biochemical Journal · 1994 · 981 citations · Full text

, , +24

A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration

Koichi Masuda, Yoichi Aota, Carol Muehleman et al. · Spine · 2005 · 712 citations