Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

Abstract

This work explains the curious predominance in human melanoma of mutations of codon 61 of NRAS over other oncogenic NRAS mutations. Using conditional "knock-in" mouse models, we show that physiologic expression of NRASQ61R, but not NRASG12D, drives melanoma formation.