Elevated cerebrospinal fluid levels of prostaglandin E2 and 15<i>‐(S)‐</i>hydroxyeicosatetraenoic acid in multiple sclerosis

Abstract

These data suggest no direct involvement of PGE2 and 15(S)-HETE in the MS disease process. Rather, the elevated levels reflect a general up-regulation of arachidonic acid metabolism and neuroinflammation.