Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions

Abstract

PdII-catalyzed Michael reactions of β-dicarbonyl compounds 1 and enones 2 can generate quaternary stereocenters (shown in yellow) with selectivities of 90 % ee at relatively high temperatures (−10 °C). This method represents a breakthrough in enantioselective synthesis.