Endotoxin contamination contributes to the pulmonary inflammatory and functional response to<i>Aspergillus fumigatus</i>extract inhalation in heaves horses

Abstract

This study supports a role for other inhalants, in addition to soluble components of A. fumigatus, in the aetiopathogenesis of heaves. Also the amplification in response to LPS when inhaled with A. fumigatus extract, suggests that the role of inhaled endotoxin in the pulmonary inflammation and dysfunction in naturally occurring heaves may currently be underestimated.