AT1 Receptor Antagonist Restores Cardiac Ryanodine Receptor Function, Rendering Isoproterenol-Induced Failing Heart Less Susceptible to Ca2+-Leak Induced by Oxidative Stress

Abstract

Chronic beta-receptor-stimulation did not induce any Ca(2+)-leak from the SR, whereas Ca(2+)-leak was easily induced when oxidative stress was applied to the PKA-phosphorylated RyR2. Candesartan not only improved Ca(2+)-uptake, but also prevented PKA-phosphorylation, rendering the SR less susceptible to Ca(2+)-leak.