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Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP

Neurodegenerative DiseasesAlzheimer's DiseaseLysosomal AlkalizationA246e MutationNatural SciencesMolecular BiologyDisease-linked Presenilin 1Degenerative DiseaseDegenerative PathologyNeurologyNeurodegenerationCellular BiochemistryBrain PathologyMedicineCell BiologyLysosomal Storage Disease