Effective Treatment of Head and Neck Squamous Cell Carcinoma by An Oncolytic Herpes Simplex Virus

Abstract

NV1020 is an oncolytic HSV that displays efficient replication and oncolysis in human HNSCC lines in vitro. Injection of NV1020 into murine flank tumors demonstrated effective tumor regression. Treatment of HNSCC with NV1020 is a promising form of therapy with potential clinical applicability in humans.