Synthetic Analogues for Oxovanadium(<scp>IV</scp>)–Glutathione Interaction: An EPR, Synthetic and Structural Study of Oxovanadium(<scp>IV</scp>) Compounds with Sulfhydryl‐Containing Pseudopeptides and Dipeptides

Abstract

Glutathione, which is found in millimolar concentrations in all animal cells, plays an important role in the biochemistry of vanadium. Sulfhydryl-containing peptides (or pseudopeptides) are ideal for the synthesis of analogues of the VIVO2+–glutathione species; such compounds were synthesized and characterized. Possible structures for the VIVO2+–glutathione center (shown here) at various pHs are proposed.