Antagonists of growth hormone‐releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells

Abstract

This study demonstrates for the first time that GHRH can act as a growth factor in BPH-1 cells and that GHRH antagonists can reverse its stimulatory effect. New observations are provided on the mechanism of action of GHRH antagonists in BPH. Our findings support the merit of further work on the development of GHRH antagonists for therapy of BPH.