Synthesis of substituted <i>N</i>‐(2,4‐dioxo‐1,2,3,4‐tetrahydroquinazolinyl)benzamides and <i>N</i>‐(2‐thiono‐4‐oxo‐1,2,3,4‐tetrahydroquinazolinyl)benzamides

Abstract

Abstract Substituted N ‐(2,4‐Dioxo‐1,2,3,4‐tetrahydroquinazolinyl)benzamides ( 3a‐g ) and substituted N ‐(2‐Thiono‐4‐oxo‐1,2,3,4‐tetrahydroquinazolinyl)benzamides ( 4a‐g ) were synthesized in one step from the reaction of methyl anthranilate with 2‐aryl‐1,3,4‐oxadiazolin‐5‐ones ( 1a‐g ) and 2‐aryl‐1,3,4‐oxadiazoline‐5‐thiones ( 2a‐g ), respectively, in m ‐cresol at 150–160°. Alternative routes leading to the formation of 3a and 4a are also reported.