Concepedia

Publication | Open Access

The absence of macrophage Nrf2 promotes early atherogenesis

DOIFull Paper Access

107

Citations

32

References

2013

Year

Anna‐Kaisa Ruotsalainen, Matias Inkala, Mervi E. Partanen, Jari P. Lappalainen, Emilia Kansanen, Petri I. Mäkinen, Suvi Heinonen, Heidi M. Laitinen, Janne Heikkilä, Tero Vatanen,
Cardiovascular Research

Abstract

Nrf2 deficiency specific to bone marrow-derived cells aggravates atherosclerosis in LDLR(-/-) mice. Furthermore, the loss of Nrf2 in macrophages enhances foam cell formation and promotes the pro-inflammatory phenotype.

References

YearCitations

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