Aged Mice Exhibit Greater Mortality Concomitant to Increased Brain and Plasma TNF-α Levels following Intracerebroventricular Injection of Lipopolysaccharide

Abstract

These results suggest that the age-related increases in TNF-alpha production and mortality following the intracerebroventricular administration of LPS may be due to an increased endotoxin hypersensitivity of brain microglia/macrophages within aged animals.