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Effect of Thyrocalcitonin on Calcium Exchange in Rat Tissues
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1965
Year
Animal PhysiologyMechanobiologyMolecular PhysiologyMedicineThyrocalcitonin ActionPhysiologyParathyroid HormoneCalcium ExchangeOsteoporosisTibial BoneThyroid HormoneHour TissueEndocrinologyPharmacologyCellular PhysiologyBone MetabolismOsteocalcinHealth Sciences
One hour tissue and cellular exchangeable pools of calcium of various soft tissues and tibial bone were measured in thyrocalcitonin-treated and control rats using 47Ca as a tracer. Thyrocalcitonin consistently caused a small, albeit insignificant, decrease in the exchangeable pools of pancreas, liver, kidney, skeletal muscle and bone and a significant 30 % decrease in the exchangeable pool of myocardium. These data indicate that the action of thyrocalcitonin to lower extracellular calcium concentrations is not mediated by increased soft tissue uptake of calcium. An enhanced osseous uptake of calcium also does not appear to be involved in thyrocalcitonin action. (Endocrinology77: 1151, 1965)