Mecamylamine Suppresses Basal and Nicotine-Stimulated Choroidal Neovascularization

Abstract

These data suggest that endogenous activation of nAChR promotes CNV and that activation of nAChR by nicotine may contribute to the increased incidence of CNV seen in smokers with age-related macular degeneration (AMD). Topically administered mecamylamine could provide an appealing new treatment approach for CNV.