Induction of nasal hyper‐responsiveness by allergen challenge in allergic rhinitis: the role of afferent and efferent nerves

Abstract

Allergen exposure in asymptomatic allergic subjects leads to induction of neural reflexes, resulting in nasal hyper-responsiveness, which persists beyond the resolution of the acute allergic response. Our data suggest that the mechanisms of allergen-induced hyper-responsiveness involve both afferent and efferent components.