Growth Inhibitory Activity of a Bis-Benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and -Prism

Abstract

Two new supramolecular coordination complexes (SCCs), were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, <b>4</b>, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism <b>6</b> selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC₅₀ values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.