Chemical constituents of Artocarpus camansi

Abstract

The dichloromethane extract of the leaves of Artocarpus camansi afforded friedelinol (1), squalene (2), β-sitosterol (3), stigmasterol (4) and phytol (5), while the stems yielded polyprenol (6), cycloartenol (7) and cycloartenol acetate (8). The structures of 1, 7 and 8 were elucidated by extensive 1D and 2D NMR spectroscopy. The cytotoxicity of these triterpenes were tested using the sulforhodamine B assay against the human cancer cell lines: lung adenocarcinoma A549 cells, stomach adenocarcinoma AGS cells, colon adenocarcinoma HT29 cells and prostate cancer PC3 cells. Results of the study indicated that 1, 7 and 8 are non-cytotoxic against these cell lines.