Salivary Interleukin‐6, Matrix Metalloproteinase‐8, and Osteoprotegerin in Patients With Periodontitis and Diabetes

Abstract

Salivary IL-6 concentrations were elevated in patients with periodontitis with or without diabetes. Salivary MMP-8 and OPG concentrations were elevated regardless of periodontal inflammation in patients with diabetes. Therefore, periodontitis and diabetes are conditions that may interfere with protein expression and should be considered when using saliva for diagnoses.