Clinical implications of matrix metalloproteinase‐1, ‐3, ‐7, ‐9, ‐12, and plasminogen activator inhibitor‐1 gene polymorphisms in colorectal cancer

Abstract

MMP1-1,607 dupG and MMP9-1,562 C homozygotes demonstrated an increased risk of colorectal cancer regardless of ethnic differences, whereas other MMP and PAI1 polymorphisms did not. Nevertheless, specific MMP haplotypes on 11q22.1-23.3 and 20q12-13 seem to be implicated in susceptibility to colorectal cancer.