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Application of the Benzyloxycarbonyloxymethyl Moiety to a Protective Group of 5-Fluorouracil. Selective Alkylation of Amide Nitrogen of the Uracil Ring
16
Citations
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References
1988
Year
Medicinal ChemistryDerivative (Chemistry)EngineeringProtective GroupUracil RingAmide NitrogenNatural SciencesFluorous SynthesisOrganic ChemistryChemistryHeterocycle ChemistryAbstract Selective AlkylationSynthetic ChemistryBiomolecular Engineering
Abstract Selective alkylation of 5-fluorouracil using the benzyloxycarbonyloxymethyl moiety as a protective group of amide nitrogen of the uracil ring is described. Protection, alkylation and deprotection were carried out in high yields.
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