Subcorneal colocalization of the small heat shock protein, hsp27, with keratins and proteins of the cornified cell envelope

Abstract

These results provide morphological evidence that in normal human skin hsp27 might act as a chaperone of cornification. Investigations of the molecular hsp27 interactions with the proteins of the cornified cell envelope are necessary to gain further insight into terminal keratinocyte differentiation and disorders of keratinization.