Concepedia

Publication | Open Access

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

DOIFull Paper Access

795

Citations

47

References

2008

Year

Kristine Nograles, Lisa C. Zaba, Emma Guttman‐Yassky, Judilyn Fuentes‐Duculan, Mayte Suárez‐Fariñas, Irma Cardinale, Artemis Khatcherian, Juana Gonzalez, Katherine C. Pierson, Traci R. White,
British Journal of Dermatology

Abstract

Our results suggest that the Th17 cytokines IL-17 and IL-22 mediate distinct downstream pathways that contribute to the psoriatic phenotype: IL-17 is more proinflammatory, while IL-22 retards keratinocyte differentiation.

References

YearCitations

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