The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients - Concepedia

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The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients

DOI Full Paper Access

61

Citations

29

References

2008

Year

Hector Chinoy, Hazel Platt, Janine A. Lamb, Zoë Betteridge, Harsha Gunawardena, Noreen Fertig, Hemlata Varsani, JE Davidson, Chester V. Oddis, N. McHugh,

Arthritis & Rheumatism

Abstract

The R620W variant is a significant risk factor for IIM, independent of the HLA 8.1 haplotype. Unlike that in the HLA region, risk is not increased in individuals possessing MSAs/MAAs. These results are further evidence that the PTPN22 gene confers autoimmune susceptibility.

References

	Year	Citations

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