Selective Reduction of Central Pulse Pressure Under Angiotensin Blockage in SHR: Role of the Fibronectin- 5 1 Integrin Complex

Abstract

Results showed that amlodipine and trandolapril have different effects on carotid mechanical properties for comparable MBP reduction. Changes in Fn-integrin complex not only modify consistently ACEI mechanotransduction but also are associated with selective central PP reduction. Whether this property has consequences on cardiovascular (CV) risk remains to be investigated.