Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Abstract

RBP4 is an adipocyte-secreted molecule that is elevated in the serum before the development of frank diabetes and appears to identify insulin resistance and associated cardiovascular risk factors in subjects with varied clinical presentations. These findings provide a rationale for antidiabetic therapies aimed at lowering serum RBP4 levels.