Bioactive Bone Cement Based on CaO─SiO ₂ ─P ₂ O ₅ Glass

Abstract

A CaO─SiO 2 ─P 2 O 5 ─CaF 2 glass powder hardened within 4 min when mixed with an ammonium phosphate solution to form CaNH 4 PO 4 ·H 2 O. After it had soaked in a simulated body fluid for 3 d, forming hydroxyapatite, the cement showed a compressive strength of 80 MPa. Implanted into a rat tibia, the mixed paste formed a tight chemical bond to the living bone within 4 weeks. Such a bioactive cement could be useful not only for fixing various kinds of implants to the surrounding bones but also, by itself, as a bone filler.