Advanced Materials · 2007 · 209 citations · 12 references
EngineeringMolecular BiologyColloidal NanocrystalsMulticolor Quantum DotsBiomedical EngineeringNanomedicineBiomarker (Medicine)Cancer DetectionQuantum DotsBreast Cancer BiomarkersBiomarker DiscoveryMolecular DiagnosticsBiophysicsBiomarker TargetTumor TargetingCell BiologyTumor MicroenvironmentSingle-molecule DetectionTumor BiomarkersBreast CancerSitu Molecular ProfilingQuantum Dot BioconjugatesMedicine
Quantum dot bioconjugates can be used for multiplexed and quantitative detection of tumor biomarkers in cells and tissues. This new technology should have significant impact on molecular pathology if validated with traditional techniques (such as western blotting, FISH, and IHC), and with large-scale clinical studies. In addition, it could also become the first clinical application of quantum dots.
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In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology · 2004 · 4.7K citations
Multiplexed Toxin Analysis Using Four Colors of Quantum Dot Fluororeagents
Ellen R. Goldman, Aaron R. Clapp, George P. Anderson et al. · Analytical Chemistry · 2003 · 648 citations
Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry
Yun Xing, Qaiser Chaudry, Christopher Shen et al. · Nature Protocols · 2007 · 518 citations