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Synthesis and radioprotective activity of new cysteamine and cystamine derivatives
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1986
Year
Pharmaceutical ScienceCystamine Salt DerivativesOrganic ChemistryChemistryHeterocycle ChemistryChemical DerivativePharmaceutical ChemistryMedicinal ChemistryInteresting CompoundsDerivativesBiochemistryStructure-activity RelationshipsPharmacologyHeterocyclicNatural SciencesNew CysteamineMedicineDerivative (Chemistry)Synthetic ChemistryDrug DiscoveryDrug Analysis
A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.