Characterization of the Fetal Blood Transcriptome and Proteome in Maternal Anti‐Fetal Rejection: Evidence of a Distinct and Novel Type of Human Fetal Systemic Inflammatory Response

Abstract

We describe a systemic inflammatory response in human fetuses born to mothers with evidence of maternal anti-fetal rejection. The transcriptome and proteome of this novel type of fetal inflammatory response were different from that of FIRS type I (which is associated with acute infection/inflammation).