Characterization of a Canine Model of Autosomal Recessive Retinitis Pigmentosa due to a<i>PDE6A</i>Mutation

Abstract

This represents the first characterization of a PDE6A model of autosomal recessive retinitis pigmentosa, and the PDE6A mutant dog shows promise as a large animal model for investigation of therapies to rescue mutant rod photoreceptors and to preserve cone photoreceptors in the face of a rapid loss of rod cells.