Method for Measuring Capillary Permeability and its Use in Patients with Skin Disease

Abstract

Alterations in capillary permeability in disease have not proved easy to measure. Methods used previously include measure- ment of haematocrit and plasma protein before and after a period of venous congestion (Landis, Jonas, Angevine, and Erb, 1932), measurement of disappearance from plasma of Evans blue (T 1824) (Weinbren, 1963) and 131I human serum albumin (Ismail, Khalifa, and Madwar, 1965), and simultaneous deter- mination of plasma volume by T 1824 and high-molecular- weight dextran (Verel, 1958). This is a report of a new method and of the findings obtained with it in patients with skin disease.