Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

Nikola P. Pavletich, Carl O. Pabo · Science · 1991 · 2.1K citations

Crystal Structure, Structural Bioinformatics, Molecular Biology +16

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty et al. · Science · 1999 · 1.7K citations

Molecular Biology, Small Molecule Inhibitor, Cytoskeleton +18

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

Takenobu Katagiri · The Journal of Cell Biology · 1994 · 1.4K citations · Full text

Sclerostin, Cellular Physiology, Osteoporosis +19

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

Kaveh Ashrafi, Francesca Chang, Jennifer L. Watts et al. · Nature · 2003 · 983 citations

Genome-wide Rnai Analysis, Transcriptional Regulation, Genetics +5

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

Dominique Sanglard, Karl Kuchler, Françoise Ischer et al. · Antimicrobial Agents and Chemotherapy · 1995 · 814 citations · Full text

Specific Multidrug Transporters, Antifungal Agent, Azole Resistance +15