<i><scp>HER</scp>2</i> and <i><scp>EGFR</scp></i> gene copy number alterations are predominant in high‐grade salivary mucoepidermoid carcinoma irrespective of <i><scp>MAML</scp>2</i> fusion status

Abstract

These results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC comprises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status.