Canadian Journal of Chemistry · 1988 · 16 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructure-activity RelationshipsSynthetic Medicinal ChemistryAntifungal AgentsAntifungal PharmacologyHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsFungicidal BioassaysHeterocyclic AromaticityHeterocyclic ReactivityMedicinal HeterocyclesThiazole ChemistryThiazole Synthesis
(Isothiazol-5-yl)diarylcarbinols were prepared from 5-lithioisothiazole. (Thiazol-5-yl)diarylcarbinols were obtained via 5-lithio-2-bromothiazole or 5-lithio-2-trimethylsilylthiazole with subsequent removal of the 2-substituent. Corresponding 2-aminothiazol-5-ylcarbinols were made by protecting 2-aminothiazole as its bis(trimethylsilyl) derivative. Biological activities were compared to the calculated electron densities at the heterocyclic N-atoms.