First trimester prenatal diagnosis of 21-hydroxylase deficiency by linkage analysis to HLA-DNA probes and by 17-hydroxyprogesterone determination

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.

Perrin C. White, Dario Grossberger, Barbara J. Onufer et al. · Proceedings of the National Academy of Sciences · 1985 · 492 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

CLOSE GENETIC LINKAGE BETWEEN HLA AND CONGENITAL ADRENAL HYPERPLASIA (21-HYDROXYLASE DEFICIENCY)

Bo Dupont, Sharon E. Oberfield, Elizabeth M. Smithwick et al. · The Lancet · 1977 · 372 citations

Life Sciences, Endocrinology, Genetics +11

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

Ashwani Sood, Danielle Dutra Pereira, S M Weissman · Proceedings of the National Academy of Sciences · 1981 · 372 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

Kenth Gustafsson, Klas G. Wiman, Eva Emmoth et al. · The EMBO Journal · 1984 · 233 citations · Full text

Life Sciences, Genetics, Immunology +12